Generic Name: paclitaxel protein-bound (PAK li TAX el PRO teen-bound)
Brand Names: Abraxane
What is paclitaxel protein-bound?
Paclitaxel protein-bound is a cancer medication that interferes with the growth and spread of cancer cells in the body.
Paclitaxel protein-bound is used in the treatment of breast cancer.
Paclitaxel protein-bound is usually given after other cancer medicines have been tried without successful treatment.
Paclitaxel protein-bound may also be used for purposes not listed in this medication guide.
What is the most important information I should know about paclitaxel protein-bound?
Do not use paclitaxel protein-bound if you are pregnant. It could harm the unborn baby. Use birth control to prevent pregnancy while you are receiving paclitaxel protein-bound, whether you are a man or a woman. Paclitaxel protein-bound use by either parent may cause birth defects. You should not use paclitaxel protein-bound if you are allergic to it, or if you have a low white blood cell count.
Before you receive this medication, tell your doctor if you have kidney disease, liver disease, heart disease, or bone marrow suppression.
To make sure this medication is helping your condition and not causing harmful effects, your blood will need to be tested often. Your cancer treatments may be delayed based on the results of these tests. Do not miss any follow-up visits to your doctor.
Call your doctor at once if you have a serious side effect such as fever, chills, flu symptoms, mouth sores, easy bruising or bleeding, pale skin, feeling light-headed or short of breath, swelling or rapid weight gain, chest pain, sudden cough, rapid heart rate, or trouble breathing.
What should I discuss with my healthcare provider before receiving paclitaxel protein-bound?
You should not use paclitaxel protein-bound if you are allergic to it, or if you have a low white blood cell count.
To make sure you can safely receive paclitaxel protein-bound, tell your doctor if you have any of these other conditions:
kidney disease;
liver disease;
heart disease; or
bone marrow suppression.
FDA pregnancy category D. Do not use paclitaxel protein-bound if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment. Use birth control to prevent pregnancy while you are receiving paclitaxel protein-bound, whether you are a man or a woman. Paclitaxel protein-bound use by either parent may cause birth defects. It is not known whether paclitaxel protein-bound passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are receiving paclitaxel protein-bound.
How is paclitaxel protein-bound given?
Paclitaxel protein-bound is injected into a vein through an IV. You will receive this injection in a clinic or hospital setting. Paclitaxel protein-bound must be given slowly, and the IV infusion can take at least 30 minutes to complete.
Paclitaxel protein-bound is usually given once every 3 weeks. Follow your doctor's dosing instructions very carefully.
Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when paclitaxel protein-bound is injected.
To make sure this medication is helping your condition and not causing harmful effects, your blood will need to be tested often. Your cancer treatments may be delayed based on the results of these tests. Do not miss any follow-up visits to your doctor.
What happens if I miss a dose?
Call your doctor for instructions if you miss an appointment for your paclitaxel protein-bound injection.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose symptoms may include some of the serious side effects listed in this medication guide.
What should I avoid while using paclitaxel protein-bound?
Paclitaxel protein-bound can be harmful if it gets in your eyes, mouth, or nose, or on your skin. If skin contact occurs, wash the area with soap and water or rinse the eyes thoroughly with plain water.
Paclitaxel protein-bound side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:
fever, chills, body aches, flu symptoms, sores in your mouth and throat;
easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating;
feeling like you might pass out;
swelling, rapid weight gain; or
chest pain, sudden cough, wheezing, trouble breathing, fast heart rate.
Less serious side effects may include:
numbness or tingly feeling;
muscle or joint pain;
nausea, vomiting;
diarrhea; or
hair loss.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect paclitaxel protein-bound?
Tell your doctor about all other medicines you use, especially:
bosentan (Tracleer);
conivaptan (Vaprisol);
imatinib (Gleevec);
isoniazid (for treating tuberculosis);
montelukast (Singulair) or zafirlukast (Accolate);
rifampin (Rifater, Rifadin, Rifamate);
selegiline (Eldepryl, Emsam, Zelapar);
an antibiotic such as clarithromycin (Biaxin), dalfopristin/quinupristin (Synercid), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin), or telithromycin (Ketek);
an antidepressant such as nefazodone or fluoxetine (Prozac);
antifungal medication such as clotrimazole (Mycelex Troche), itraconazole (Sporanox), ketoconazole (Extina, Ketozole, Nizoral, Xolegal), or voriconazole (Vfend);
a blood thinner such as warfarin (Coumadin);
cancer medication such as paclitaxel (Taxol) or tamoxifen (Soltamox);
heart or blood pressure medications such as amiodarone (Cordarone, Pacerone), carvedilol (Coreg), diltiazem (Cartia, Cardizem), felodipine (Plendil), losartan (Hyzaar, Cozaar), nifedipine (Nifedical, Procardia), torsemide (Demadex), verapamil (Calan, Covera, Isoptin, Verelan), and others;
HIV/AIDS medicine such as atazanavir (Reyataz), delavirdine (Rescriptor), fosamprenavir (Lexiva), indinavir (Crixivan), nelfinavir (Viracept), saquinavir (Invirase), or ritonavir (Norvir);
seizure medications such as fosphenytoin (Cerebyx), or phenytoin (Dilantin);
oral diabetes medication such as glimepiride (Amaryl), glipizide (Glucotrol), nateglinide (Starlix), pioglitazone (Actos, Actoplus Met), repaglinide (Prandin), rosiglitazone (Avandia, Avandamet), or tolbutamide (Orinase); or
sulfa drugs (Bactrim, Gantanol, Gantrisin, Septra, SMX-TMP, and others).
This list is not complete and other drugs may interact with paclitaxel protein-bound. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
More Abraxane resources
- Abraxane Side Effects (in more detail)
- Abraxane Use in Pregnancy & Breastfeeding
- Abraxane Drug Interactions
- Abraxane Support Group
- 1 Review for Abraxane - Add your own review/rating
- Abraxane Prescribing Information (FDA)
- Abraxane Advanced Consumer (Micromedex) - Includes Dosage Information
- Abraxane MedFacts Consumer Leaflet (Wolters Kluwer)
- Abraxane Consumer Overview
Compare Abraxane with other medications
- Breast Cancer
- Breast Cancer, Metastatic
Where can I get more information?
- Your doctor or pharmacist can provide more information about paclitaxel protein-bound.
See also: Abraxane side effects (in more detail)
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