pralatrexate

Generic Name: pralatrexate (PRAL a TREX ate)

Brand Names: Folotyn

What is pralatrexate?

Pralatrexate is a cancer medication.

Pralatrexate is used to treat T-cell lymphoma that has spread throughout the body.

Pralatrexate is given for relapsed T-cell lymphoma, or after other medications have been tried without successful treatment.

Pralatrexate may also be used for purposes not listed in this medication guide.

What is the most important information I should know about pralatrexate?

Before you receive pralatrexate, tell your doctor if you have kidney disease.

Do not use pralatrexate if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment. You should not breast-feed a baby while you are being treated with pralatrexate. You may be required to take oral folic acid supplements and receive vitamin B12 injections to help prevent some of the side effects of pralatrexate. Follow your doctor's medication instructions very closely. To make sure this medication is not causing harmful effects, your blood will need to be tested often. Your cancer treatments may be delayed based on the results of these tests. Do not miss any follow-up visits to your doctor. Call your doctor at once if you have a serious side effect such as fever, flu symptoms, mouth ulcers, easy bruising or bleeding, pale skin, rapid heart rate, trouble breathing, weakness, or feeling like you might pass out.

What should I discuss with my health care provider before receiving pralatrexate?

You should not receive this medication if you are allergic to it.

To make sure you can safely use pralatrexate, tell your doctor if you have kidney disease.

FDA pregnancy category D. Do not use pralatrexate if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment. It is not known whether pralatrexate passes into breast milk or if it could harm a nursing baby. You should not breast-feed a baby while you are being treated with pralatrexate.

How is pralatrexate given?

Pralatrexate is injected into a vein through an IV. You will receive this injection in a clinic or hospital setting.

Pralatrexate is usually given once per week for up to 6 weeks at a time. Follow your doctor's instructions.

You may be required to take daily folic acid supplements starting 10 days before your first dose of pralatrexate and ending 30 days after your last dose. Your doctor may also give you injections of vitamin B12 every 8 to 10 weeks while you are being treated with pralatrexate.

Using vitamin B12 and folic acid can help protect your blood cells from some of the side effects of pralatrexate. Follow your doctor's medication instructions very closely.

To make sure this medication is not causing harmful effects, your blood will need to be tested often. Your cancer treatments may be delayed based on the results of these tests. Do not miss any follow-up visits to your doctor.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your pralatrexate injection.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include some of the serious side effects listed in this medication guide.

What should I avoid while receiving pralatrexate?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Pralatrexate side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:

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  taste loss, mouth pain, redness or ulcers, or white-yellow mouth sores;

  
  


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  easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;

  
  


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  fever, chills, body aches, flu symptoms, rapid heart rate, rapid and shallow breathing, fainting;

  
  


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  pale skin, feeling light-headed or short of breath, trouble concentrating;

  
  


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  weakness, decreased sweating, hot or dry skin; or

  
  


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  confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling.

  
  

Less serious side effects may include:

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  nausea, vomiting, loss of appetite;

  
  


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  diarrhea, constipation;

  
  


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  tired feeling;

  
  


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  cough;

  
  


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  swelling; or

  
  


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  mild rash or itching.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Pralatrexate Dosing Information

Usual Adult Dose for Lymphoma:

For use in the treatment of Peripheral T-cell Lymphoma:

Recommended dose: 30 mg/m2 administered as an intravenous push over 3 to 5 minutes once weekly for 6 weeks in 7 week cycles, until progressive disease or unacceptable toxicity.

Patients should take low dose (1 mg to 1.25 mg) oral folic acid on a daily basis. Folic acid should be initiated during the 10 day period preceding the first dose of pralatrexate, and dosing should continue during the full course of therapy and for 30 days after the last dose of pralatrexate. Patients should also receive a vitamin B12 (1 mg) intramuscular injection no more than 10 weeks prior to the first dose of pralatrexate and every 8 to 10 weeks thereafter. Subsequent vitamin B12 injections may be given the same day as treatment with pralatrexate.

What other drugs will affect pralatrexate?

Tell your doctor about all other medications you use, especially:

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  probenecid (Benemid);

  
  


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  trimethoprim (Bactrim, Proloprim, Septra, SMX-TMP); or

  
  


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  aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) such as ibuprofen (Motrin, Advil), diclofenac (Cataflam, Voltaren), etodolac (Lodine), indomethacin (Indocin), nabumetone (Relafen), naproxen (Aleve, Naprosyn), meloxicam (Mobic), piroxicam (Feldene), and others.

  
  

This list is not complete and other drugs may interact with pralatrexate. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More pralatrexate resources

• Pralatrexate Side Effects (in more detail)
• Pralatrexate Dosage
• Pralatrexate Use in Pregnancy & Breastfeeding
• Pralatrexate Drug Interactions
• Pralatrexate Support Group
• 0 Reviews for Pralatrexate - Add your own review/rating

• pralatrexate Intravenous Advanced Consumer (Micromedex) - Includes Dosage Information


• Folotyn Prescribing Information (FDA)


• Folotyn Consumer Overview


• Pralatrexate Professional Patient Advice (Wolters Kluwer)


• Pralatrexate Monograph (AHFS DI)


• Pralatrexate MedFacts Consumer Leaflet (Wolters Kluwer)

Compare pralatrexate with other medications

• Lymphoma
• Non-Hodgkin's Lymphoma
• Peripheral T-cell Lymphoma

Where can I get more information?

• Your doctor or pharmacist can provide more information about pralatrexate.

See also: pralatrexate side effects (in more detail)